The 290-metre corroding cruise ship will later today be towed from Giglio, the Italian island it struck two-and-a-half-years ago - a maritime disaster that killed 32 people.
It will start its four day voyage to Genoa, northern Italy, travelling past the French island of Corsica and through a whale and dolphin reserve.
Corsicans have reportedly dubbed the liner a 'maritime Chernobyl,' The Times reports, as it drags 12 tonnes of toxic products and polluted seawater to its final destination.
However, escorting the 115,000 tonne liner will be a flotilla of anti-pollution and safety vessels.
'Rigorous and constant' checks will be carried out on the ship, Italy has confirmed, amid concerns from neighbouring France that its own seas could be affected.
Last week it was revealed that Segolene Royal, the French Environment Minister, had written to her counterpart in Italy, Gian Luca Galletti, demanding 'written and incontrovertible proof' that the ship's fuel tanks had been emptied, the Telegraph reports.
The liner's final route to Genoa had still not been finalised by last Thursday, further riling French officials.
It was due to be moved on Monday but rough seas and final checks to the mammoth vessel hampered its scheduled departure time.
The Costa Concordia will be broken up for spare parts when it arrives in Genoa, following one of the largest maritime salvage operations in history.
The ship was brought upright in September and last Monday, salvage workers gradually lifted the luxury cruise ship from the sea floor by pumping air into 30 large metal boxes attached to the hull, known as sponsons.
The ship's captain, Francesco Schettino, is on trial facing charges of manslaughter, which he denies.
One remaining body still hasn't been recovered by divers - that of Indian waiter Russel Rebello, though Italian officials have pledged to continue to search for him.
Entities 0 Name: Genoa Count: 3 1 Name: Italy Count: 3 2 Name: Italian Count: 2 3 Name: Costa Concordia Count: 1 4 Name: The Times Count: 1 5 Name: Corsica Count: 1 6 Name: Giglio Count: 1 7 Name: France Count: 1 8 Name: Gian Luca Galletti Count: 1 9 Name: French Count: 1 10 Name: Russel Rebello Count: 1 11 Name: Francesco Schettino Count: 1 12 Name: Segolene Royal Count: 1 Related 0 Url: http://ift.tt/1A4mwtC Title: Costa Concordia sets sail on final voyage Description: Giglio, Italy (CNN) -- The wrecked Costa Concordia cruise ship has begun its final voyage. Salvage crews refloated the ship last week so they can move it from its resting place off Giglio Island to the Italian port of Genoa to be dismantled. On Wednesday morning, it set sail.
